A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

Cohesin is a ring-shaped protein complex that topologically entraps DNA to fulfil key functions in chromosome architecture. In a multidisciplinary approach, Higashi et  al. use cryo-EM and biochemical techniques to describe how ATP-fueled structural changes of the cohesin complex drive the DNA entry reaction into the cohesin ring.

Source: Molecular Cell - August 3, 2020 Category: Cytology Authors: Torahiko L. Higashi, Patrik Eickhoff, Joana S. Sousa, Julia Locke, Andrea Nans, Helen R. Flynn, Ambrosius P. Snijders, George Papageorgiou, Nicola O ’Reilly, Zhuo A. Chen, Francis J. O’Reilly, Juri Rappsilber, Alessandro Costa, Frank Uhlmann Tags: Article Source Type: research