Phenylglyoxylic Acid: An Efficient Initiator for the Photochemical Hydrogen Atom Transfer (HAT) C-H Functionalization of Heterocycles.

Phenylglyoxylic Acid: An Efficient Initiator for the Photochemical Hydrogen Atom Transfer (HAT) C-H Functionalization of Heterocycles.
ChemSusChem. 2020 Aug 24;:
Authors: Papadopoulos GN, Kokotou MG, Spiliopoulou N, Nikitas NF, Voutyritsa E, Tzaras DI, Kaplaneris N, Kokotos CG
Abstract
C-H functionalization at the α position of heterocycles has become a rapidly growing area of research. Herein, we report a cheap and efficient photochemical method for the C-H functionalization of heterocycles. PhCOCOOH can behave as an alternative to metal-based catalysts and organic dyes and provides a very general and wide array of photochemical C-H alkylation, alkenylation and alkynylation, as well as C-N bond forming reaction methodologies. This novel, mild and metal-free protocol is successfully employed in the functionalization of a wide range of C-H bonds, utilizing not only O - or N -heterocycles, but also the less studied S -heterocycles.
PMID: 32833347 [PubMed - as supplied by publisher]

Source: ChemSusChem - August 23, 2020 Category: Chemistry Authors: Papadopoulos GN, Kokotou MG, Spiliopoulou N, Nikitas NF, Voutyritsa E, Tzaras DI, Kaplaneris N, Kokotos CG Tags: ChemSusChem Source Type: research