Pre ‐implantation genetic testing for aneuploidy: the past, present and future

AbstractKey content Embryonic aneuploidy is often found in women undergoing assisted reproduction and is a common cause of poor outcomes, particularly in women of advanced maternal age and those with recurrent miscarriage and repetitive implantation failure. The aim of pre ‐implantation genetic testing for aneuploidy (PGT‐A) is to select the most competent embryo for transfer, thus improving reproductive outcome. Initial PGT‐A techniques failed to show an improvement in delivery rates and, in some trials, demonstrated inferior outcomes; however, advances in tec hnology, combined with robust culture media and vitrification techniques, have significantly improved outcomes. Recent debate has argued for the increased clinical application of PGT‐A, particularly in women of advanced maternal age; we provide an overview of PGT‐A, including its past and assoc iated limitations, the evolution in technology and latest outcomes, and address potential future implicationsLearning objectives To understand the rationale behind the use of PGT ‐A. To review the evidence against and in favour of PGT‐A. To understand the new techniques being used and how these have led to emerging evidence in favour of PGT‐A.
Source: The Obstetrician and Gynaecologist - Category: OBGYN Authors: Tags: REVIEW Source Type: research