Prognostic and Predictive Molecular Biomarkers in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is a malignancy of B cells with a variable clinical course. Prognostication is important to place patients into different risk categories for guiding decisions on clinical management, to treat or not to treat. Although several clinical, cytogenetic, and molecular parameters have been established, in the past decade, a tremendous understanding of molecular lesions has been obtained with the advent of high-throughput sequencing. Meanwhile, rapid advances in the understanding of the CLL oncogenic pathways have led to the development of small-molecule targeting signal transducers, tyrosine-protein kinase BTK and phosphatidylinositol 3-kinase, as well as anti-apoptotic protein apoptosis regulator Bcl-2.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Review Source Type: research