Myogenic cell expression of intercellular adhesion molecule-1 (ICAM-1) contributes to muscle regeneration after injury.

Myogenic cell expression of intercellular adhesion molecule-1 (ICAM-1) contributes to muscle regeneration after injury.
Am J Pathol. 2020 Jul 07;:
Authors: Martin RA, Buckley KH, Mankowski DC, Riley BM, Sidwell AN, Douglas SL, Worth RG, Pizza FX
Abstract
We investigated intercellular adhesion molecule-1 (ICAM-1), a membrane protein that mediates cell-to-cell adhesion and communication, as a mechanism through which the inflammatory response facilitates muscle regeneration after injury. Toxin-induced muscle injury to tibialis anterior muscles of wild type mice caused ICAM-1 to be expressed by a population of satellite cells/myoblasts and myofibers. Myogenic cell expression of ICAM-1 contributed to the restoration of muscle structure after injury, as regenerating myofibers were more abundant and myofiber size was larger for wild type compared to ICAM-1-/- mice during 28 d of recovery. Contrastingly, restoration of muscle function after injury was similar between the genotypes. ICAM-1 facilitated the restoration of muscle structure after injury through mechanisms involving the regulation of myofiber branching, protein synthesis, and the organization of nuclei within myofibers after myogenic cell fusion. Our findings provide support for a paradigm in which ICAM-1 expressed by myogenic cells after muscle injury augments their adhesive and fusogenic properties, which in turn facilitates regenerative and hypertrophic processes that restore s...

Source: The American Journal of Pathology - July 6, 2020 Category: Pathology Authors: Martin RA, Buckley KH, Mankowski DC, Riley BM, Sidwell AN, Douglas SL, Worth RG, Pizza FX Tags: Am J Pathol Source Type: research