Formation of Boron Enolates by Nucleophilic Substitution

Synlett DOI: 10.1055/s-0040-1707181 Enolates have proven to be one of the key building blocks available to the synthetic chemist. Here we summarize a novel strategy for their preparation, involving the addition of α-borylated nucleophiles to esters to yield boron enolates. The enolates prepared by the addition of lithiated geminal bis(boron) compounds to esters can be trapped with two equivalents of halogen and alkyl electrophiles to yield α,α-difunctionalized compounds.1 Introduction2 Ketone Difunctionalization3 Boron Enolates by Coupling4 Towards Sequential Trapping5 Summary and Outlook [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - July 8, 2020 Category: Chemistry Authors: Garratt, George R. A. Pattison, Graham Tags: synpacts Source Type: research