2-Aminoquinazolines by Chan –Evans–Lam Coupling of Guanidines with (2-Formylphenyl)boronic Acids

Synlett DOI: 10.1055/s-0040-1707080 A new method is presented for the synthesis of 2-aminoquinazolines, which is based on a Chan–Evans–Lam coupling of (2-formylphenyl)boronic acids with guanidines. Relatively mild conditions involving the use of inexpensive CuI as a catalyst and methanol as a solvent permit the application of the method to a wide range of substrates. Nonsubstituted, N-monosubstituted, and N,N-disubstituted guanidines can be used as reactants to give the corresponding 2-aminoquinazolines in moderate yields from readily available (2-formylphenyl)boronic acids. [...] Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text

Source: Synlett - July 7, 2020 Category: Chemistry Authors: Solomin, Vitalii V. Seins, Alberts Jirgensons, Aigars Tags: letter Source Type: research