High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function

The intestinal barrier protects intestinal cells from microbes and antigens in the lumen —breaches can alter the composition of the intestinal microbiota, the enteric immune system, and metabolism. We performed a screen to identify molecules that disrupt and support the intestinal epithelial barrier and tested their effects in mice.

Source: Gastroenterology - July 7, 2020 Category: Gastroenterology Authors: Inna Grosheva, Danping Zheng, Maayan Levy, Omer Polansky, Alexandra Lichtenstein, Ofra Golani, Mally Dori-Bachash, Claudia Moresi, Hagit Shapiro, Sara Del Mare-Roumani, Rafael Valdes-Mas, Yiming He, Hodaya Karbi, Minhu Chen, Alon Harmelin, Ravid Straussma Source Type: research