Untangling lifespan and body mass discrepancies in canids: Phylogenetic comparison of oxidative stress in blood from domestic dogs and wild canids.

Untangling lifespan and body mass discrepancies in canids: Phylogenetic comparison of oxidative stress in blood from domestic dogs and wild canids. Am J Physiol Regul Integr Comp Physiol. 2020 Jul 01;: Authors: Jimenez AG, Downs CJ Abstract Canids are a morphological and physiological diverse group of animals, with the most diversity found within one species, the domestic dog. Underlying the observed morphological differences must be cellular-level differences that could lead to elucidating aging rates and lifespan disparities between wild and domestic canids. Furthermore, small breed dogs live significantly longer lives than large breed dogs while having higher mass-specific metabolic rates and faster growth rates. At the cell level, a clear mechanism underlying whole-animal traits has not been fully elucidated, though, oxidative stress has been implicated as a potential culprit of the disparate lifespans of domestic dogs. We used separated blood from known age domestic dogs and wild canids, and measured several oxidative stress variables: total antioxidant capacity (TAC), lipid damage, and enzymatic activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). We used phylogenetically corrected analysis and non-phylogenetically corrected analysis. We found that lipid damage increases with age in domestic dogs; whereas TAC increases with age and TAC and GPx activity increase as a function of age/Maximum...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research