The impact of oxytocin on thiol/disulphide and malonyldialdehyde/glutathione homeostasis in stressed rats.

The impact of oxytocin on thiol/disulphide and malonyldialdehyde/glutathione homeostasis in stressed rats. Biol Chem. 2020 Jun 01;: Authors: Korkmaz H, Önal D, Alışık M, Erel Ö, Pehlivanoğlu B Abstract We aimed to investigate the impact of oxytocin on serum thiol/disulphide and malonylyldialdehyde (MDA)/glutathione balance under acute and chronic stress exposure in rats. Animals were allocated into control (C), acute (AS) and chronic stress (CS) groups, then the groups subdivided as intranasal oxytocin or saline applied groups, randomly. Animals in the AS or CS groups were exposed to combined cold-immobilisation stress. Salivary corticosterone levels and elevated-plus maze (EPM) scores were used to assess stress response. Malonylyldialdehyde, glutathione, thiol-disulphide levels were measured in the serum samples. Oxytocin treatment attenuated stress response regardless of the stress duration verified by lower corticosterone level and favorable profile in EPM parameters measured. Furthermore, oxytocin modulated oxidant profile suggesting lowered oxidant stress with decreased serum malonylyldialdehyde/glutathione and disulfide/native thiol ratios. Oxytocin improves the response of organism to stress via both its anxiolytic and antioxidant effects. That's why it can be considered as a protective measure to employ methods to increase endogenous oxytocin and/or to apply exogenous oxytocin to prevent stress-induced increase in oxida...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research