The Central Role of Osteocytes in the Four Adaptive Pathways of Bone’s Mechanostat

We review evidence supporting an updated mechanostat model in bone that highlights the central role of osteocytes within bone's four mechanoadaptive pathways: 1) formation modeling and 2) targeted remodeling, which occur with heightened mechanical loading, 3) resorption modeling, and 4) disuse-mediated remodeling, which occur with disuse. These four pathways regulate whole-bone stiffness in response to changing mechanical demands.

Source: Exercise and Sport Sciences Reviews - June 20, 2020 Category: Sports Medicine Tags: Articles Source Type: research