Influence of selected polymorphisms in disposition genes on lumefantrine pharmacokinetics when coadministered with efavirenz

Conclusion
The findings revealed that the efavirenz–lumefantrine interaction was accentuated in the group with CYP2B6 c.516T, c.983C and NR1I3 152c-1089T alleles. This warrants further investigations of other drug–drug interactions for optimising dosing in genetically defined subgroups, particularly during drug development.

Source: Pharmacogenetics and Genomics - June 6, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research