Intrinsically Noncombustible Polymers without Flame Retardant Additives: Sulfur-containing and Bio-based Benzoxazines
Publication date: Available online 23 May 2020Source: European Polymer JournalAuthor(s): Ya Lyu, Yuting Zhang, Hatsuo Ishida
AbstractCohen syndrome (CS) is an autosomal recessive congenital disorder, characterized by hypotonia, intellectual disability, developmental delay, microcephaly, progressive retinopathy, neutropenia, truncal obesity, joint laxity, characteristic facial, ophthalmic, oral and appendage abnormalities, and an over friendly behavior. It has been linked to mutations in theVPS13B gene. The main purpose of this study was to determine the genetic cause of CS in an Indian family. Whole exome sequencing (WES) was used to identify the genetic cause of CS in the family. The WES analysis identified a homozygous novel duplication mutati...
AbstractIntracerebral hemorrhage (ICH) is a non-traumatic cerebrovascular disorder with very high morbidity and mortality and regarded as one of the deadliest stroke subtypes. Notably, there is no effective treatment for ICH. Despite an overall increase in preclinical studies, the pathophysiology of ICH is complex and remains enigmatic. To this end, ICH was induced in male CD-1 mice and the ipsilateral brain tissue was characterized in an unbiased manner using a combination of proteomics and bioinformatics approaches. A total of 4833 proteins were revealed by quantitative proteomic analysis. Of those, 207 proteins ex...
Two national studies find pathologists bill out-of-network more frequently than other hospital-based specialties, and one study links that behavior to insurer reimbursement rates Surprise bills for out-of-network services continue to be an important issue for healthcare consumers. Now comes a recently-released report from the Health Care Cost Institute (HCCI) claiming that pathologists are the specialists […]
Publication date: Available online 11 July 2020Source: Innovative Food Science &Emerging TechnologiesAuthor(s): Katarzyna Rybak, Katarzyna Samborska, Aleksandra Jedlinska, Oleksii Parniakov, Malgorzata Nowacka, Dorota Witrowa-Rajchert, Artur Wiktor
In this study, UGT activities were analyzed in liver (five lobes) and small intestine (the duodenum and six sections from the proximal jejunum to the distal ileum) using typical probe substrates of human UGTs: 7-hydroxycoumarin, estradiol, serotonin, propofol, and zidovudine. In liver, UGT activities with respect to all substrates were detected, and the activity levels were similar in all liver lobes of the cynomolgus macaques tested. In contrast, in the small intestine, UGT activities toward all substrates were detected, but their levels generally decreased from jejunum to ileum in cynomolgus macaques. The localization of...
Authors: Kabeya T, Mima S, Imakura Y, Miyashita T, Ogura I, Yamada T, Yasujima T, Yuasa H, Iwao T, Matsunaga T Abstract To develop a novel intestinal drug absorption system using intestinal epithelial cells derived from human induced pluripotent stem (iPS) cells, the cells must possess sufficient pharmacokinetic functions. However, the CYP3A4/5 activities of human iPS cell-derived small intestinal epithelial cells prepared using conventional differentiation methods is low. Further, studies of the CYP3A4/5 activities of human iPS-derived and primary small intestinal cells are not available. To fill this gap in our k...
Publication date: Available online 11 July 2020Source: Veterinary MicrobiologyAuthor(s): Shengkui Xu, Dongjie Chen, Dengjin Chen, Qianlin Hu, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Hanchun Yang
Authors: Carapetis JR, Brown A PMID: 32652580 [PubMed - as supplied by publisher]
Publication date: Available online 11 July 2020Source: Annals of PhysicsAuthor(s): Alberto Escalante, Aldair Pantoja
Publication date: Available online 11 July 2020Source: Annals of PhysicsAuthor(s): Mohamed Moussa
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