Continual Improvement of the Reliability of EML4-ALK Rearrangement Detection in Non –Small-Cell Lung Cancer

The results of EML4-ALK testing are critical to manage ALK inhibitor treatment. Thus, the accurate detection of ALK rearrangement is increasingly becoming a matter of serious concern. To address this issue, a long-term EML4-ALK proficiency testing (PT) scheme was launched in China in 2015, serving as an educational tool for assessing and improving the testing quality of EML4-ALK fusion detection. Responses across 20 different PT samples interrogating three different variants and wild-type samples were collected between 2015 and 2019.

Source: Journal of Molecular Diagnostics - April 13, 2020 Category: Pathology Authors: Rongxue Peng, Rui Zhang, Jiawei Zhang, Ping Tan, Yanxi Han, Kuo Zhang, Guigao Lin, Jiehong Xie, Jinming Li Source Type: research