CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms
British Journal of Cancer, Published online: 18 May 2020; doi:10.1038/s41416-020-0891-xCDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms
Publication date: Available online 4 July 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Lingling Zhou, Jiulong Zhao, Yongkang Chen, Yuting Zheng, Jinfeng Li, Jiayan Zhao, Jing Zhang, Yiyun Liu, Xiuying Liu, Shige Wang
Publication date: Available online 5 July 2020Source: European UrologyAuthor(s): Alan H. Bryce, Oliver Sartor, Johann de Bono
Publication date: Available online 4 July 2020Source: European UrologyAuthor(s): Friedemann Krentel, Roland Seiler
(Wiley) New research found that the likelihood of being diagnosed with advanced cancer decreased among individuals with low income after expansion of Medicaid coverage. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS).
Publication date: October 2020Source: Pharmacological Research, Volume 160Author(s): Shengda Luo, Jiahui Xu, Zebo Jiang, Lei Liu, Qibiao Wu, Elaine Lai-Han Leung, Alex Po Leung
Publication date: September 2020Source: Biomedicine &Pharmacotherapy, Volume 129Author(s): Yi Lu, Runzhe Zhang, Xinjie Zhang, Bo Zhang, Qinghua Yao
Psychologist was due to get life-saving NHS cancer treatment until coronavirus struckCoronavirus – latest updatesSee all our coronavirus coverageA psychologist denied access to a potentially life-saving cancer drug trial because NHS services were suspended due to Covid-19 is trying to raise £240,000 to buy the medicine privately.Wendy Peake said it was “shocking, absolutely shocking” that she and her husband, Andrew, were having to use their savings, draw down pension money and remortgage their house to raise the money for treatment that she was due to get on the NHS until the pandemic struck.Continue reading...
o A. Soares In diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human endogenous retrovirus type K (HERV-K) expression is usually inhibited in normal cells from healthy adults. In tumor cells, however, HERV-K mRNA expression has been frequently documented to increase. Importantly, HERV-K-derived proteins can act as tumor-specific antigens, a class of neoantigens, and induce immune responses in different types of cancer. In this review, we describe the function of the HERV-K HML-2 subtype in carcinogenesis as biomarkers, and t...
Genetics in Medicine, Published online: 06 July 2020; doi:10.1038/s41436-020-0880-8Improved structural variant interpretation for hereditary cancer susceptibility using long-read sequencing
Genetics in Medicine, Published online: 06 July 2020; doi:10.1038/s41436-020-0884-4Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort