CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms

British Journal of Cancer, Published online: 18 May 2020; doi:10.1038/s41416-020-0891-xCDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research

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(Wiley) New research found that the likelihood of being diagnosed with advanced cancer decreased among individuals with low income after expansion of Medicaid coverage. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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Psychologist was due to get life-saving NHS cancer treatment until coronavirus struckCoronavirus – latest updatesSee all our coronavirus coverageA psychologist denied access to a potentially life-saving cancer drug trial because NHS services were suspended due to Covid-19 is trying to raise £240,000 to buy the medicine privately.Wendy Peake said it was “shocking, absolutely shocking” that she and her husband, Andrew, were having to use their savings, draw down pension money and remortgage their house to raise the money for treatment that she was due to get on the NHS until the pandemic struck.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: NHS Cancer Coronavirus outbreak Drugs Queen's University Belfast Health Infectious diseases Science Society UK news BBC One Media Medical research Source Type: news
o A. Soares In diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human endogenous retrovirus type K (HERV-K) expression is usually inhibited in normal cells from healthy adults. In tumor cells, however, HERV-K mRNA expression has been frequently documented to increase. Importantly, HERV-K-derived proteins can act as tumor-specific antigens, a class of neoantigens, and induce immune responses in different types of cancer. In this review, we describe the function of the HERV-K HML-2 subtype in carcinogenesis as biomarkers, and t...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Genetics in Medicine, Published online: 06 July 2020; doi:10.1038/s41436-020-0880-8Improved structural variant interpretation for hereditary cancer susceptibility using long-read sequencing
Source: Genetics in Medicine - Category: Genetics & Stem Cells Authors: Source Type: research
Genetics in Medicine, Published online: 06 July 2020; doi:10.1038/s41436-020-0884-4Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort
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