Lightening the way of hematopoiesis: infrared laser-mediated lineage tracing with high spatial-temporal resolution

Hematopoiesis is a vital developmental process, in which all blood cells including erythrocytes and leukocytes are generated. It has long been recognized that vertebrate hematopoiesis occurs in multiple waves in various anatomic sites. In mammals, the first or primitive wave of hematopoiesis initiates in the yolk sac (YS) and generates predominantly erythrocytes and macrophages [1]. Shortly after the primitive hematopoiesis, a transient erythroid/myeloid progenitor (EMP) population was observed in the YS [2,3].

Source: Experimental Hematology - May 9, 2020 Category: Hematology Authors: Sicong He, Jin Xu, Jianan Y. Qu, Zilong Wen Tags: Perspective Source Type: research