The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1

The malignant Hodgkin/Reed-Sternberg (RS) cell is embedded in a collagen-rich microenvironment. In this week's issue of Blood, Cader and colleagues elucidate a potentially important collagen-mediated signaling pathway supporting the survival of RS cells in Epstein-Barr virus-positive (EBV+) Hodgkin Disease (HD), demonstrating that expression of the EBV latent membrane protein-1 (LMP1) upregulates the expression of discoidin domain receptor 1 (DDR1), a collagen-activated receptor tyrosine kinase.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news