Lipidomics Profiling of Hidradenitis Suppurativa Skin Lesions Reveals Lipoxygenase Pathway Dysregulation and Accumulation of Pro-Inflammatory Leukotriene B4

Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory dermatosis characterized by abscesses, deep-seated nodules, sinus tracts and fibrosis in skin lesions around hair follicles of the axillary, inguinal and anogenital regions. While the exact pathogenesis remains poorly defined, clear evidence suggests that HS is a multifactorial inflammatory disease characterized by innate and adaptive immune components. Bioactive lipids are important regulators of cutaneous homeostasis, inflammation as well as resolution of inflammation.

Source: Journal of Investigative Dermatology - May 4, 2020 Category: Dermatology Authors: Carlos A. Penno, Petra J äger, Claire Laguerre, Franziska Hasler, Andreas Hofmann, Stephanie Gass, Barbara Wettstein-Ling, Dirk Schaefer, Alexandre Avrameas, Friedrich Raulf, Grazyna Wieczorek, Joachim C.U. Lehmann, Christian Loesche, Lukas Roth, Till A. Tags: Original Article Source Type: research