Featured in NEJM Journal Watch: Von Willebrand Disease — What Women's Health Clinicians Need to Know (FREE)

By the NEJM Journal Watch Editors The American College …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

Related Links:

Publication date: Available online 17 October 2019Source: Journal of Molecular BiologyAuthor(s): Alexander Tischer, Maria A. Brehm, Venkata R. Machha, Laurie Moon-Tasson, Linda M. Benson, Katelynn J. Nelton, Rachel R. Leger, Tobias Obser, Marina Martinez-Vargas, Steven T. Whitten, Dong Chen, Rajiv K. Pruthi, H. Robert Bergen, Miguel A. Cruz, Reinhard Schneppenheim, Matthew AutonAbstractVon Willebrand factor (VWF), an exceptionally large multimeric plasma glycoprotein, functions to initiate coagulation by agglutinating platelets in the blood stream to sites of vascular injury. This primary hemostatic function is perturbed i...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 17 October 2019Source: Journal of Molecular BiologyAuthor(s): Alexander Tischer, Maria A. Brehm, Venkata R. Machha, Laurie Moon-Tasson, Linda M. Benson, Katelynn J. Nelton, Rachel R. Leger, Tobias Obser, Marina Martinez-Vargas, Steven T. Whitten, Dong Chen, Rajiv K. Pruthi, H. Robert Bergen, Miguel A. Cruz, Reinhard Schneppenheim, Matthew AutonAbstractVon Willebrand factor (VWF), an exceptionally large multimeric plasma glycoprotein, functions to initiate coagulation by agglutinating platelets in the blood stream to sites of vascular injury. This primary hemostatic function is perturbed i...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Abstract Heavy menstrual bleeding is common in adolescents. The frequency and predictors of bleeding disorders in adolescents, especially with anovulatory bleeding, are unknown. Adolescents referred for heavy menstrual bleeding underwent an evaluation of menstrual bleeding patterns, and bleeding disorders determined a priori. The primary outcome was the diagnosis of a bleeding disorder. Two groups were compared: anovulatory and ovulatory bleeding. Multivariable logistic regression analysis of baseline characteristics and predictors was performed. Kaplan Meier curves were constructed for the time from the first ble...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
Authors: Rodriguez-Merchan EC Abstract Introduction: The purpose of this article is to review which data about hemophilia are currently provided by the Cochrane database of systematic reviews (CDBSR). Methodological consideration: All statements about hemophilia in the Cochrane Collaboration are based on evidence generated in randomized controlled clinical trials. Areas covered: There is a high degree of evidence that prophylaxis preserves joint function in children with hemophilia compared to on-demand treatment. Also, that recombinant factor VII activated (rFVIIa) and activated prothrombin complex concentrates (A...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
To describe the post-surgical outcome in patients with a history of von Willebrand's disease undergoing minimally invasive surgery.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 1: Laparoscopy (9:50 AM — 10:00 AM) 9:50 AM: STATION F Source Type: research
AbstractStudies have shown that microRNAs (miRNAs) participate in almost all pathological and physiological processes including acute lower ‐extremity deep venous thrombosis (LEDVT). Here, this study was designed to elucidate the possible function of miR‐103a‐3p in acute LEDVT. Expression of miR‐103a‐3p and chemokine C‐X‐C motif ligand 12 (CXCL12) was initially quantified in plasma collected from 81 LEDVT patients. Then LE DVT mouse models were established by injection with 3% sodium pentobarbital. The interaction between miR‐103a‐3p and CXCL12 was identified by dual‐luciferase reporter gene assay. Afte...
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research
We present a 3D coarse-grained computer model of VWF multimers in flowing viscous fluid that explicitely grasps the dynamics, the conformational changes and the hydrodynamics-induced activation of adhesivity of these protein concatamers to GPIb receptor of blood platelets. The model is based on the fluctuating Lattice Boltzmann method for modelling the hydrodynamics in the simulation box and the Lagrangian particle dynamics coupled to the fluid by a viscous drag force. The model has been validated by the comparison with the experimental data found in literature. We studied the effect of hydrophobic interactions on the conf...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Abstract The proband's von Willebrand factor (VWF) antigen and VWF collagen-binding capacity were 14% and 10%, respectively; his sister's were 16% and 9%, respectively; and his nephew's were 30% and 15%, respectively. No apparent loss of high-molecular weight VWF multimers was observed in the plasma of these patients. A single-nucleotide substitution of T to C was found at nucleotide position 113042 in their VWF gene, converting Leu1733 to Pro in the A3 domain. These results suggest that p.Leu1733Pro is responsible for type 2M von Willebrand disease in this family. PMID: 31605304 [PubMed - as supplied by publisher]
Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research
Bansal et al. demonstrated that the fully magnetically levitated centrifugal-flow HeartMate3 (HM3) left ventricular assist device is associated with greater preservation of the structure of vWF HMWMs than the HeartMateII (HMII) mechanical bearing axial-flow pump.1 The findings confirm our prior work regarding the development of AVWS in VAD patients and the less distinct loss of the vWF high molecular weight multimers in HM3 patients compared with HMII patients.2,3 However, there are some differences: Bansal et al.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
In this study we analyzed the quality and quantity of the structure of vWF by using mulitmer gel electrophoresis and also evaluated VWF functional activities, including platelet glycoprotein I β binding (VWF:Act LIA) and Factor VIII activity, to assess for acquired vWD (aVWD) with commercially available methods that are used in clinical practice and previously validated in congenital vWD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
More News: Health | Primary Care | von Willebrand Disease | Women