A lncRNA Decoy Predicts Sensitivity to Cisplatin.

A lncRNA Decoy Predicts Sensitivity to Cisplatin. Trends Mol Med. 2020 Apr;26(4):352-354 Authors: Boque-Sastre R, Guil S Abstract In a recent iScience paper by Fan et al., the long noncoding (lnc)RNA CISAL is shown to form a DNA-RNA triplex and to directly regulate BRCA1 transcription, thereby increasing cisplatin sensitivity and serving as a treatment efficacy biomarker. This opens promising avenues of research from both mechanistic and translational perspectives. PMID: 32277928 [PubMed - as supplied by publisher]
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Tags: Trends Mol Med Source Type: research