Reply to Srinivas Chilukuri et al: The toxicity data from POP-RT: Proving the “Obvious” and challenging the “Norm”

We thank the authors for bringing to our attention the previously reported association between significant genitourinary (GU) toxicity and absolute bladder volume exposed to 30-40 Gy during image guided proton therapy [1]. We had focused primarily on trials and data related to photon dosimetry. This information actually lends credence to the validity of our dosimetric observation that medium dose levels may be important determinant for symptomatic GU toxicity. We await the corresponding data from PIVOTAL and RTOG 0924 trials with interest.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research