Patients on Steroids With COVID-19 Might Need Rescue Steroids

Those on steroids because of known adrenal disease, and for more common ailments, may need additional 'stress' doses of IV corticosteroids in the case of severe infection with COVID-19, endocrinologists urge.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Source: BMJ Comments - Category: General Medicine Source Type: forums
Abstract Acute lung injury (ALI) represents the most severe form of the viral infection sustained by coronavirus disease 2019 (COVID-19). Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome-coronavirus) are today used with a mild or moderate effect on the lung injury. In fact, ALI seems to be related to the inflammatory burst and release of proinflammatory mediators that i...
Source: The Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: J Clin Pharmacol Source Type: research
The use of corticosteroids in coronavirus infections is associated with increased risk of death and side effects, such as bacterial infections and hypokalaemia, researchers have said.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
PMID: 32437628 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
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Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
Corticosteroids appear to worsen COVID-19 outcomes in patients with IBD, but TNF antagonists do not, according to an international registry study.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases News Source Type: news
Corticosteroids, when taken by a pregnant woman at high risk of delivering a premature infant, can help accelerate infant lung development and reduce the risk of respiratory distress syndrome, systemic infections, and death. However, such exposure may also come with long-term risks of mental and behavioral disorders in these children, particularly if they are ultimately full term, suggests astudy published today inJAMA.“[C]orticosteroids cross the placenta and the blood-brain barrier and may harm fetal brain development,” wrote Katri Räikkönen, Ph.D., of the University of Helsinki and colleagues. &ldq...
Source: Psychiatr News - Category: Psychiatry Tags: behavioral disorder blood-brain barrier corticosteroids development JAMA Katri R äikkönen mental disorder premature risks Sara DeMauro vulnerable infants Source Type: research
TUESDAY, May 19, 2020 -- For patients with inflammatory bowel disease (IBD) and COVID-19, risk factors for severe disease include increasing age, comorbidities, and systemic corticosteroids, according to a study published online May 18 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Source: Critical Care - Category: Intensive Care Authors: Tags: Research Letter Source Type: research
(University of North Carolina Health Care) The researchers conclude that increasing age, comorbidities, and corticosteroids are associated with severe COVID-19 among IBD patients. Notably, TNF antagonists do not appear to be associated with severe COVID-19.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
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