Patients on Steroids With COVID-19 Might Need Rescue Steroids
Those on steroids because of known adrenal disease, and for more common ailments, may need additional 'stress' doses of IV corticosteroids in the case of severe infection with COVID-19, endocrinologists urge.
Abstract Acute lung injury (ALI) represents the most severe form of the viral infection sustained by coronavirus disease 2019 (COVID-19). Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome-coronavirus) are today used with a mild or moderate effect on the lung injury. In fact, ALI seems to be related to the inflammatory burst and release of proinflammatory mediators that i...
The use of corticosteroids in coronavirus infections is associated with increased risk of death and side effects, such as bacterial infections and hypokalaemia, researchers have said.
PMID: 32437628 [PubMed - as supplied by publisher]
Corticosteroids appear to worsen COVID-19 outcomes in patients with IBD, but TNF antagonists do not, according to an international registry study.Reuters Health Information
Corticosteroids, when taken by a pregnant woman at high risk of delivering a premature infant, can help accelerate infant lung development and reduce the risk of respiratory distress syndrome, systemic infections, and death. However, such exposure may also come with long-term risks of mental and behavioral disorders in these children, particularly if they are ultimately full term, suggests astudy published today inJAMA.“[C]orticosteroids cross the placenta and the blood-brain barrier and may harm fetal brain development,” wrote Katri Räikkönen, Ph.D., of the University of Helsinki and colleagues. &ldq...
TUESDAY, May 19, 2020 -- For patients with inflammatory bowel disease (IBD) and COVID-19, risk factors for severe disease include increasing age, comorbidities, and systemic corticosteroids, according to a study published online May 18 in...
(University of North Carolina Health Care) The researchers conclude that increasing age, comorbidities, and corticosteroids are associated with severe COVID-19 among IBD patients. Notably, TNF antagonists do not appear to be associated with severe COVID-19.