Emanating the specialty clinical practices in Ayurveda: Preliminary observations from the Arthritis clinic and its implications

Publication date: Available online 1 April 2020Source: Journal of Ayurveda and Integrative MedicineAuthor(s): Sanjeev Rastogi
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research

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In the lumbar spinal cord dorsal horn, release of afferent nerve glutamate activates the neurons that relay information about injury pain. Here, we examined the effects of protein tyrosine kinase (PTK) inhibition on NMDA receptor NR1 subunit protein expression and subcellular localization in an acute experimental arthritis model. PTK inhibitors genistein and lavendustin A reduced cellular histological translocation of NMDA NR1 in the spinal cord occurring after the inflammatory insult and the nociceptive behavioral responses to heat. The PTK inhibitors were administered into lumbar spinal cord by microdialysis, and seconda...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Is there an association between OSA and gout? A new study investigates the possible link.Arthritis Research &Therapy
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
Guselkumab, a biologic drug approved to treat patients with moderate or severe psoriasis, significantly and safely improved psoriatic arthritis, a phase 3 trial in The Lancet concluded. Guselkumab is a human monoclonal antibody that inhibits interleukin-23.
Source: JAMA - Category: General Medicine Source Type: research
Rheumatoid arthritis (RA), a chronic systemic inflammatory disease, is a primary cause of disability worldwide. The involvement of fibroblast-like synoviocytes (FLSs) in the regulation of the pathogenesis of RA has been highlighted. Mesenchymal stem cells (MSCs) are important candidates for cell-based treatment in many inflammatory autoimmune diseases. Herein, we identify whether MSC-derived exosomes loaded with microRNA-320a (miR-320a) regulate RA-FLSs. Synovial tissues from 22 patients with RA and 9 patients with osteoarthritis were collected. RA-FLSs were obtained from patients with RA, and their functions were evaluate...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Cell Death &Disease, Published online: 26 May 2020; doi:10.1038/s41419-020-2609-7P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
This article has been amended to include open access.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
ConclusionsA complex interaction between RA disease and fertility related issues is present. Despite an increase rate of infertility in RA females or males, the mechanisms involved in this outcome is still unknown. Plausible causes of the decreased fertility rate in RA patients might be due to inflammatory cytokines, suppressed sexual activity, drug treatments, mother age, personal choice, or a combination of these elements.
Source: Inflammation Research - Category: Research Source Type: research
Mycoplasma bovis causes pneumonia, pharyngitis, otitis, arthritis, mastitis, and reproductive disorders in cattle and bison. Two multilocus sequence typing (MLST) schemes have been developed for M. bovis, with one serving as the PubMLST reference method, but no comparison of the schemes has been undertaken. Although the PubMLST scheme has proven to be highly discriminatory and informative, the recent discovery of isolates missing one of the typing loci, adh-1, raises concern about its suitability for continued use. The goal of our study was to compare the performance of the two MLST schemes and identify a new reference sch...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Clinical Veterinary Microbiology Source Type: research
ConclusionThe PopPK/PD models showed numerically greater reductions in DAS28-CRP and ANC with sarilumab 200  mg every 2 weeks than with 150 mg every 2 weeks. There was no clinically meaningful influence of investigated covariates. These data contribute to the totality of evidence that supports a sarilumab subcutaneous starting dose of 200 mg every 2 weeks, with a subsequent reduction to 150 mg ever y 2 weeks in the event of laboratory abnormalities such as neutropenia.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
AbstractPurpose of the ReviewReactive arthritis is synovitis related to an infection away from the joint. The evolution is variable, frequently self-limited, but with the possible evolution to a prolonged form, generating functional incapacity and sequelae.Recent FindingsNew microbiological families have been incriminated and pathophysiological links have been clarified, highlighting the role of the mucous membranes (gut in particular), specific cell populations, and the production of pro-inflammatory cytokines. First-line pharmacological treatment is based on NSAIDs. In case of failure, synthetic and more recently biologi...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
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