Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos

Despite next-generation sequencing, which now allows for the accurate detection of segmental aneuploidies from in  vitro fertilization embryo biopsies, the origin and characteristics of these aneuploidies are still relatively unknown. Using a multifocal biopsy approach (four trophectoderms [TEs] and one inner cell mass [ICM] analyzed per blastocyst; n = 390), we determine the origin of the aneuploidy and the d iagnostic predictive value of segmental aneuploidy detection in TE biopsies toward the ICM’s chromosomal constitution.

Source: The American Journal of Human Genetics - March 25, 2020 Category: Genetics & Stem Cells Authors: Laura Girardi, Munevver Serdarogullari, Cristina Patassini, Maurizio Poli, Marco Fabiani, Silvia Caroselli, Onder Coban, Necati Findikli, Fazilet Kubra Boynukalin, Mustafa Bahceci, Rupali Chopra, Rita Canipari, Danilo Cimadomo, Laura Rienzi, Filippo Ubald Tags: Article Source Type: research