Rosacea is Characterized by a Profoundly Diminished Skin Barrier

Rosacea is a common, chronic inflammation of sebaceous gland-rich facial skin characterized by severe skin dryness, elevated pH, transepidermal water loss, and decreased hydration levels. Until now, there has been no thorough molecular analysis of permeability barrier alterations in the skin of rosacea patients. Thus, we aimed to investigate the barrier alterations in papulopustular rosacea (PPR) samples compared to healthy sebaceous gland-rich (SGR) skin, using RNASeq analysis (n=8). Pathway analyses by Cytoscape ClueGo revealed 15 significantly enriched pathways related to skin barrier formation.

Source: Journal of Investigative Dermatology - March 18, 2020 Category: Dermatology Authors: Barbara Medgyesi, Zsolt Dajnoki, Gabriella B éke, Krisztián Gáspár, Imre Lőrinc Szabó, Eszter Anna Janka, Szilárd Póliska, Zoltán Hendrik, Gábor Méhes, Dániel Törőcsik, Tamás Bíró, Anikó Kapitány, Andrea Szegedi Tags: Original Article Source Type: research