Synthesis and biological effects of naphthalene-chalcone derivatives

AbstractIn this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds2a –2u displayed clear antidepressant activity at 30  mg/kg in the forced swimming test. Compounds2h,2o,2t, and2u exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30  mg/kg. Compounds2h,2o,2t, and2u but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound2o is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds2a –2u also showed the analgesic and anti-inflammatory effects at 30  mg/kg.

Source: Medicinal Chemistry Research - March 12, 2020 Category: Chemistry Source Type: research