Diffusion weighted imaging improves diagnostic ability of MRI for determining complete response to neoadjuvant therapy in locally advanced rectal cancer
Publication date: 2020Source: European Journal of Radiology Open, Volume 7Author(s): Anuradha Chandramohan, Umar M. Siddiqi, Rohin Mittal, Anu Eapen, Mark R. Jesudason, Thomas S. Ram, Ashish Singh, Dipti Masih
Neoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed Death...
Operation is the standard of care after neoadjuvant chemoradioterapy. Therefore a nonoperative management (W&W) has been proposed as an option for patients who achieve a complete clinical response by exclusive chemoradiotherapy. This approach is still investigational and we compared outcomes between patients in this group with those who had a complete pathologic response after surgical resection to address whether W&W approach has an oncologic efficacy in terms of overall survival, disease-free survival, local relapse, and distant relapse, and also whether it should be implemented in clinical practice.
Neoadjuvant chemoradiotherapy has become the standard treatment for locally advanced rectal cancer. Watchful waiting (WW) strategy was used in a few patients with clinical complete response (cCR).
Previous studies have shown high rates of positive circumferential resection margin (CRM) after proctectomy in the US. We sought to explore whether widespread deployment of neoadjuvant therapy has impacted the national rate of positive CRM.
We present a cost-effectiveness analysis of WW protocols vs abdominal-perineal-resection (APR)/low-anterior-resection (LAR) for rectal cancer patients with complete clinical response after chemoradiation.
Publication date: Available online 28 September 2020Source: Practical Radiation OncologyAuthor(s): Fiore Michele, Greco Carlo, Coppola Roberto, Caricato Marco, Caputo Damiano, Trecca Pasquale, Floreno Barnaba, Rinaldi Carla Germana, Ippolito Edy, Capolupo Gabriella Teresa, Grippo Raffaele, Beomonte Zobel Bruno, D’Angelillo Rolando Maria, Trodella Lucio, Ramella Sara
ConclusionsOur case-matched study suggested that a TD tube does not reduce the AL rate after laparoscopic sphincter-saving surgery for rectal cancer.
Conditions: Rectal Cancer Stage; Oesophageal Cancer Interventions: Radiation: CRT; Radiation: SCPRT; Radiation: CROSS Protocol; Diagnostic Test: PD-L1 PET Sponsors: Johannes Laengle, MD, PhD; Christian Doppler Laboratory Applied Metabolomics Not yet recruiting