Reduction of Nitrite to NO at a Mononuclear Copper(II)-Phenolate Site

This report illustrates the synthesis and structural characterization of a novel mononuclear nitritocopper(II) complex [L1]Cu(κ2-O2N) supported by a tridentate ligand bearing pyrazole and phenolate moieties. Moreover, oxygen-atom-transfer (OAT) reactivity of nitrite anion at a copper(II) site in [L1]Cu(κ2-O2N) is illustrated with a detailed kinetic analysis revealing the mechanism for the reduction of nitrite to nitric oxide. This result implies the possibility of copper(II) mediated oxygen-atom-transfer (OAT) reactivity of nitrite in the presence of oxophilic functionalities in the biological milieu.Graphical abstract

Source: Inorganica Chimica Acta - February 13, 2020 Category: Chemistry Source Type: research