The first glimpse of the endometrial microbiota in early pregnancy

Investigation of the microbial community in the female reproductive tract using sequencing techniques has revealed that endometrial samples obtained through a transvaginal catheter are dominated by Lactobacillus species. Dysbiotic changes in the endometrial microbiota may be associated with implantation failure or early spontaneous abortion in patients undergoing assisted reproductive technology (ART) treatment. Whether or not there is an endometrial microbiota in early pregnancy is unknown.Herein we describe, the human endometrial microbiota in a patient who subsequently had an 8th week spontaneous clinical miscarriage with euploid embryos in the next cycle and, for the first time, during a successful pregnancy in which the endometrial fluid was sampled at 4 weeks of gestation.

Source: American Journal of Obstetrics and Gynecology - February 8, 2020 Category: OBGYN Authors: Inmaculada Moreno, Iolanda Garcia-Grau, Davide BAU, David Perez-Villaroya, Marta Gonzalez-Monfort, Felipe Vilella, Roberto Romero, Carlos Simon Tags: Special Report Source Type: research