RNase 7 promotes sensing of self-DNA by human keratinocytes and activates an antiviral immune response.

RNase 7 is one of the major antimicrobial peptides (AMPs) secreted by keratinocytes. The AMPs hBD-2 and LL-37 promote TLR9-mediated activation of human plasmacytoid dendritic cells (pDCs) by human self-DNA; however, whether keratinocytes respond in a similar way has not yet been addressed. Keratinocytes express several receptors for the detection of cytosolic DNA. Here, we investigated the activation of keratinocytes by RNase 7 in combination with human DNA. Stimulation of keratinocytes with RNase 7 and human DNA induced a strong increase of IP-10 production.

Source: Journal of Investigative Dermatology - January 20, 2020 Category: Dermatology Authors: V. Kopfnagel, S. Dreyer, K. Baumert, M. Stark, J. Harder, K. Hofmann, M. Kleine, A. Buch, B. Sodeik, T. Werfel Tags: Original Article Source Type: research