Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

We describe the PROTAC technology and its application to drug discovery and provide examples where PROTACs have enabled novel biological insights. Furthermore, we provide a workflow for PROTAC development and use and discuss the benefits and issues associated with PROTACs. Finally, we compare PROTAC-mediated protein-level modulation with other technologies, such as RNAi and genome editing.

Source: Cell - January 17, 2020 Category: Cytology Source Type: research