Hepatitis C virus associated lymphoplasmacytic lymphoma with Waldenstrӧm macroglobulinemia: response to direct-acting antiviral therapy

Publication date: Available online 14 January 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Yenny Alejandra Moreno Vanegas, Ridas Juskevicius, Bhagirathbhai Dholaria
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 21 February 2020Source: Antiviral ResearchAuthor(s): Rashmi Kumari, Zhu Guo, Amrita Kumar, Mayim Wiens, Shivaprakash Gangappa, Jacqueline M. Katz, Nancy J. Cox, Renu B. Lal, Devanand Sarkar, Paul B. Fisher, Adolfo García-Sastre, Takashi Fujita, Vijay Kumar, Suryaprakash Sambhara, Priya Ranjan, Sunil K. LalAbstractInfluenza virus non-structural protein 1 (NS1) counteracts host antiviral innate immune responses by inhibiting Retinoic acid inducible gene-I (RIG-I) activation. However, whether NS1 also specifically regulates RIG-I transcription is unknown. Here, we identify a CCAAT/Enh...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 22 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Andrea BUSNELLI, Amerigo VITAGLIANO, Laura MENSI, Stefano ACERBONI, Alessandro BULFONI, Francesca FILIPPI, Edgardo SOMIGLIANAAbstractSeveral epidemiological studies investigated the effects of cancer therapies on fertility. However, conflicting data have been reported.The present systematic review and meta-analysis aims to determine the chances of childbirth in women survived from different types of cancer.We systematically searched Pubmed, MEDLINE, Embase and Scopus, from database inception to July 17, 2019, for published ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Abstract Seven members of signaling lymphocytic activation molecule (SLAM) family receptors (SFRs) are ubiquitously expressed on hematopoietic cells and they play critical roles in immune cell differentiation and activation. The engagement of these receptors transmits intracellular signaling mainly by recruiting SLAM-associated protein (SAP) and its related adaptors, EWS-FLI1-activated transcript-2 (EAT-2) and EAT-2-related transducer (ERT). The critical roles of SFRs and SAP-family adaptors are highlighted by the discovery that SAP is mutated in human X-linked lymphoproliferative (XLP1) disease in which the conta...
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Tags: Adv Immunol Source Type: research
Authors: Siedlecka-Kroplewska K, Wozniak M, Kmiec Z Abstract Resveratrol is a naturally occurring polyphenolic compound present in many plant species and wine. It possesses a wide range of beneficial biological properties including anticancer activity. Resveratrol has been demonstrated to induce both autophagy and apoptosis in several human cancer cell lines. The aim of this study was to investigate whether resveratrol modulates autophagy and apoptosis in MOLT-4 human lymphoblastic leukemia and HL-60 human promyelocytic leukemia cells. Cell viability was evaluated by the neutral red uptake assay. Cell cycle distrib...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Authors: Smith AM, Zhang CRC, Cristino AS, Grady JP, Fink JL, Moore AS Abstract [This corrects the article DOI: 10.18632/oncotarget.27206.]. PMID: 32076493 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 21 February 2020Source: Journal of Clinical and Experimental HepatologyAuthor(s): Kellie Young, Benny Liu, Taft Bhuket, Robert J. WongAbstractBackground &AimsDirect-acting antivirals (DAAs) are expected to improve outcomes for hepatitis C virus (HCV) patients following liver transplantation (LT). We aim to evaluate trends in post-LT outcomes with availability of DAAs.MethodsWe retrospectively evaluated U.S. adults transplanted from 1/1/2002 – 3/31/2018 using the United Network for Organ Sharing registry, stratified by pre-DAA (1/1/2002-12/31/2013) vs. post-DAA (1/1/2014-3/31/201...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
Publication date: Available online 22 February 2020Source: SteroidsAuthor(s): Mansour M. Nawasreh, Elham I. Alzyoud, Zainab A. Al-Mazaydeh, Majdoleen S. Rammaha, Salim R. Yasin, Lubna H. TahtamouniAbstractCephalostatin 1, a potent anti-cancer agent, is a natural bis-steroidal alkaloid that causes cell death in the subnanomolar to picomolar ranges via an atypical apoptosis pathway. Although cephalostatin 1 is a highly effective anticancer drug, its availability limits its utilization. We previously reported the synthesis of two 12'α-hydroxy derivatives of cephalostatin 1 that induce cell death by activating the ER str...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 22 February 2020Source: International Journal of PharmaceuticsAuthor(s): Sarita Rani, Rakesh K. Sahoo, Kartik T. Nakhate, Ajazuddin, Umesh GuptaAbstractBortezomib (BTZ) is a proteasome inhibitor as approved by US FDA for the treatment of multiple myeloma. It exhibits significant anti-cancer properties including against solid tumors; but lacks aqueous solubility, chemical stability which hinders its successful formulation development. The present study is an attempt to deliver BTZ using N-(2-hydroxypropyl) methacrylamide (HPMA) based copolymeric conjugates and biotinylated PNPs in an effec...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 January 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Yenny Alejandra Moreno Vanegas, Ridas Juskevicius, Bhagirathbhai Dholaria
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Lymphoplasmacytic lymphoma (LPL) with or without Waldenstr öm macroglobulinemia (WM) is a rare lymphoproliferative disorder (LPD) characterized by the presence of monoclonal immunoglobulin M (IgM) paraproteinemia and bone marrow (BM) infiltration by small lymphocytes with plasmacytoid or plasma cell differentiation.1 LPL/WM constitutes less than 5% of all non-Hodgkin lymphomas (NHLs) and 1% to 2% of hematologic malignancies.2 Patients with LPL/WM may be initially asymptomatic (smoldering WM), but over the course of their disease, they may present with fatigue, shortness of breath, anemia, lymphadenopathy (LAD), spleno...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
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