Shiitake mushroom-induced flagellate erythema: A striking case and review of the literature.
We describe a 61-year-old Caucasian man who presented with a pruritic, erythematous eruption of multiple linear streaks on the trunk and extremities starting 1 day after eating raw shiitake mushrooms. His symptoms and skin lesions resolved with minimal hyperpigmentation within approximately 1 week after treating with topical steroids and oral antihistamines. Skin biopsy showed non-specific findings, including a sparse perivascular and interstitial dermatitis as well as focal vacuolar interface changes. Our case illustrates that this condition is a visibly striking dermatitis with a self-limited course. The pathomechanism of the skin eruption remains unclear. PMID: 24021365 [PubMed - in process]
CONCLUSIONS AND CLINICAL IMPORTANCE: To the best of the authors' knowledge, the present case series documents the first known occurrence of nodular dermatitis by Straelensia spp. in red foxes. This new evidence may corroborate participation of the red fox in the life cycle of S. cynotis. PMID: 33029811 [PubMed - as supplied by publisher]
CONCLUSIONS: There were substantial differences of agreement, suggesting there are many knowledge and/or practice gaps with respect to CHE. Future research is needed to inform evidence-based and/or consensus guidelines for CHE. PMID: 32991335 [PubMed - as supplied by publisher]
CONCLUSION: With proper treatment, nummular eczema can be cleared over a few weeks, although the course can be chronic and characterized by relapses and remissions. Moisturizing of the skin and avoidance of identifiable exacerbating factors such as hot water baths and harsh soaps may reduce the frequency of recurrence. Diseases that present with annular lesions may mimic nummular eczema and the differential diagnosis is broad. As such, physicians must be familiar with this condition so that an accurate diagnosis can be made, and appropriate treatment initiated. PMID: 32778043 [PubMed - as supplied by publisher]
CONCLUSION: Our analysis of transcriptomic signatures in cutaneous disease biopsies reveals the effect of keratinocyte programming in skin inflammation and suggests that the perturbation of a single axis of immune signal alone may be insufficient to resolve keratinocyte immunophenotype abnormalities. PMID: 32730675 [PubMed - as supplied by publisher]
Our current understanding of atopic dermatitis (AD) and psoriasis pathophysiology is largely derived from skin biopsy studies that cause scarring and may be impractical in large-scale clinical trials. Although tape strips show promise as a minimally invasive technique in these common diseases, a comprehensive molecular profiling characterizing and differentiating the 2 diseases in tape strips is unavailable.
Conclusion: The findings of the present study emphasize that acne vulgaris, rosacea and seborrheic dermatitis are significantly associated with Demodex infestation. Standardized skin surface biopsy is a practical tool in the determination of Demodex infestation.
Conclusion: These data show that by using cutting-edge technology, suction blistering offers several advantages over conventional biopsies, including better transcriptomic resolution of skin cells, combined with proteomic information from interstitial fluid, unraveling novel inflammatory players that shape the cellular and proteomic microenvironment of AD.
In conclusion, we define genes with different expression patterns in CAD case skin helping us understand post-treatment atopic skin. Further studies in larger sample sets are warranted to confirm and to transfer these results into clinical practice.
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, but its complex pathogenesis is still only partly understood. To comprehensively characterize AD on both transcriptomic and proteomic levels in humans, we used skin suction blistering, a painless and non-scarring procedure that can simultaneously sample skin cells and interstitial fluid, and compared results to conventional biopsies. Suction blistering captured epidermal and most infiltrating immune cells equally well as biopsies, except for non-migratory CD163+ macrophages that were only present in biopsy isolates.
Atopic dermatitis (AD) onset usually occurs in children younger than 5 years old. While whole-skin profiling has been the gold standard for identifying AD-related biomarkers in adults, skin biopsies are not feasible in infants. An alternate minimally invasive technique to detect barrier and immune biomarkers in infants with AD is needed. We used RNA-seq to profile 20,000+ transcripts in lesional and non-lesional skin of 19 infants (0-5 y/o) with moderate-to-severe AD and 17 healthy controls. We achieved 100% detection rate of all samples, with 1,890 differentially expressed genes in lesional or non-lesional AD versus contr...