Blaschkoid lichen planus: Not a Koebner phenomenon.
Blaschkoid lichen planus: Not a Koebner phenomenon. Dermatol Online J. 2013;19(4):18187 Authors: Lade NR, Saoji V, Singh AI Abstract Linear lichen planus (LP) is commonly seen as an effect of the koebner phenomenon and can occur in any site. However, LP in a whorl pattern along Blaschko lines is rarely mentioned in the literature. We highlight this rare form in a 32-year-old female with multiple hyperpigmented lesions with various patterns along the lines of Blaschko on the left side of the trunk. The clinical and histological findings were suggestive of LP. PMID: 24021376 [PubMed - in process]
Condition: Oral Lichen Planus Intervention: Drug: Co-Enzyme Q10 mucoadhesive tablets Sponsor: Cairo University Not yet recruiting
Paras Ahmad, Usman Akhtar, Ahmed Chaudhry, Usman Rahid, Sarmad Saif, Jawaad Ahmed AsifEuropean Journal of General Dentistry 2019 8(3):55-62 Oral health is a cardinal element of nutritional as well as systemic well-being and plays a substantial part in sustaining optimum general health condition. Various factors influence oral health including metabolic diseases such as endocrine (diabetes mellitus [DM]), hematological, gastrointestinal, cutaneous, and neurological diseases. The intent of this review is to accentuate the correlation between DM and oral disorders, like those upsetting oral mucosa and supporting tissues. A r...
PMID: 31489984 [PubMed - as supplied by publisher]
Conclusion: Dermoscopy is useful in differentiating HLP and PN. Blue-gray globules, comedo-like openings, and follicular plugging were specific for HLP. Pearly white areas with white starburst pattern and red dots and globules were the specific findings in PN.
Conclusion: This study is useful in understanding the various clinical patterns of postmenopausal dermatoses and thereby help the physician, dermatologist, and gynecologist to effectively manage the conditions.
In this study, we aimed to assess the diagnostic accuracy of ex vivo CLSM in identifying histopathological features and basal membrane (BM) fluorescence with fibrinogen in lichen planus (LP) and as lupus band test in cutaneous lupus erythematosus (LE), as well as to compare its diagnostic accuracy with conventional histopathology and direct immunofluorescence (DIF) microscopy.
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease wherein cell mediated immunity plays a pivotal role. Regarding its pathogenesis, several hypotheses have been suggested. Recent studies have focused on the role of oxidative stress. 8-hydroxy-2′-deoxyguanosine (8-OHdG) is the major free radical resulted from the action of oxidative stress on nuclear and mitochondrial DNA. Considering the association of LP with hepatitis C virus (HCV) infection, the aim of our study is to evaluate 8-OHdG as an oxidative stress marker and observe the influence of HCV in LP patients.
Chronic Pruritus (CP), a primary symptom in dermatological conditions, is often intractable and strongly impacts patient quality of life. Expression of CP-related biomarkers, Oncostatin M receptor β (OSMRβ) and Interleukin-31 (IL-31), were assessed in these CP-presenting diseases: Chronic Idiopathic Pruritus (CIP), Chronic Idiopathic Urticaria (CIU), Lichen Planus (LP), and Lichen Simplex Chronicus (LSC) and correlated with clinical features. mRNA and protein expression from archived skin s amples from disease and non-pruritic control patients were analyzed by RNAscope and Immunohistochemistry (IHC) methods for I...
There are several studies showing the link between lichen planus (LP) and hepatitis C virus (HCV) infection. However, the mechanisms involved are incompletely elucidated. Investigating the implication of oxidative stress could shed some light on LP pathogenesis and its link with HCV infection. We have enrolled 12 LP patients with HCV infection (group A), 12 patients without LP, with HCV infection (group B), 31 LP patients without HCV infection (group C), and 26 healthy subjects (control group - group D).
Keratinocytes in most chronic skin inflammatory lesions are undergoing continuing oxidative stress (OS) but with distinguishing outcomes, in which lesions of oral lichen planus (OLP) feature with extensive keratinocyte apoptosis in epidermis whereas keratinocyte hyper-proliferation is a histopathologic hallmark of psoriatic lesions. Nuclear factor erythroid 2-related factor 2 (Nrf2) controls the protogenic and induced expression of antioxidant and detoxification genes in order to regulate physiological and pathological outcomes of OS, but its involvement in OLP has not been investigated.