Four new corynanthe-type alkaloids from the roots of Alstonia scholaris

Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Jian ZHANG, Hua LI, Yong LI, Zi-Wei LI, Chen-Chen SANG, Mei-Hua GAO, Dong-Mei ZHANG, Xiao-Qi ZHANG, Wen-Cai YEAbstractFour new corynanthe-type alkaloids, meloslines C–F (1–4), together with four known ones (5–8) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research