Biopsy protocol rules out surgery for women after chemo

Vacuum-assisted image-guided breast biopsy can reliably predict which breast...Read more on AuntMinnie.comRelated Reading: Why do so few women follow up on MRI-guided biopsies? BI-RADS 3 means biopsy with prior breast cancer history Same-day breast biopsies reduce healthcare disparities Sentinel lymph node biopsy unnecessary for DCIS False positives translate to higher breast cancer risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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AbstractMRI-guided vacuum-assisted breast biopsy (VABB) is used for suspicious breast cancer (BC) lesions which are detectable only with MRI: because the high sensitivity but limited specificity of breast MRI it is a fundamental tool in breast imaging divisions. We analyse our experience of MRI-guided VABB and critically discuss the potentialities of diffusion-weighted imaging (DWI) and artificial intelligence (AI) in this matter. We retrospectively analysed a population of consecutive women underwent VABB at our tertiary referral BC centre from 01/2011 to 01/2019. Reference standard was histological diagnosis or at least ...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Intra-lesion genetic heterogeneity is a common feature in DCIS synchronously diagnosed with IDC-NST. DCIS is a non-obligate precursor of IDC-NST, whose mechanisms of progression to invasive breast cancer are diverse and vary from case to case. PMID: 32220886 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
n Jing Wang To characterize molecular changes accompanying the stepwise progression to breast cancer and to identify functional target pathways, we performed miRNA and RNA sequencing using MCF10A cell lines based model system that replicates the multi-step progression involving normal, preneoplastic, ductal carcinoma in situ, and invasive carcinoma cells, where the carcinoma most resemble the basal-like subgroup of human breast cancers. These analyses suggest that 70% of miRNA alterations occurred during the initial progression from normal to a preneoplastic stage. Most of these early changes reflected a global upreg...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Karanis M, Koksal H, Ates E, Dogru O Abstract The aim of this study was to evaluate the clinical importance of fibulin-5, which has been shown to display tumour-promoting and tumour-protective functions in breast lesions. Sixty-two breast cancer patients, 19 patients with fibroadenoma, and 15 healthy breast tissues were enrolled. Forty-seven patients had invasive ductal carcinoma (IDC) (12 of them also had in situ carcinoma DCIS), and 15 had invasive lobular carcinoma (ILC). A scoring system from 0 to 4 was used to evaluate the fibulin-5 staining according to the percentage of stained cells. The median val...
Source: Polish Journal of Pathology - Category: Pathology Tags: Pol J Pathol Source Type: research
Authors: Mori N, Mugikura S, Miyashita M, Mori Y, Maekawa Y, Nagasaka T, Takase K Abstract PURPOSE: To compare the image quality between turbo spin-echo (TSE)-diffusion weighted imaging (DWI) and single-shot echo-planar imaging (EPI)-DWI, and to verify the diagnostic performance of the apparent diffusion coefficient (ADC) parameters of the two techniques by using histogram analysis in terms of differentiation between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) lesions. METHODS: Ninety-four women with 94 lesions diagnosed as breast cancer by surgery underwent IRB-approved preoperative mag...
Source: Magnetic Resonance in Medical Sciences - Category: Radiology Tags: Magn Reson Med Sci Source Type: research
CONCLUSIONS: MBC has increasing incidence. PR-negative status was associated with better overall survival and disease-free interval. Indications to radiotherapy and hormonal therapy need standardization and will benefit from prospective randomized control trials. PMID: 32147980 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Early ducts of breast tumors are unequivocally acidic. High rates of glycolysis combined with poor perfusion lead to a congestion of acidic metabolites in the tumor microenvironment, and pre-malignant cells must adapt to this acidosis to thrive. Adaptation to acidosis selects cancer cells that can thrive in harsh conditions and are capable of outgrowing the normal or non-adapted neighbors. This selection is usually accompanied by phenotypic change. Epithelial mesenchymal transition (EMT) is one of the most important switches correlated to malignant tumor cell phenotype and has been shown to be induced by tumor acidosis. Ne...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, LOY is an early event in male breast carcinogenesis, which generally starts at the DCIS stage and is associated with ER and PR negative tumors.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
We report the development of a robotic nipple-sparing mastectomy with immediate reconstruction through a single incision using the updated single-port surgical robot system for a patient with ductal carcinoma in situ (DCIS). Breast reconstruction was performed using implants. Postoperative pathological examination revealed DCIS in both breasts. There were no major immediate complications, except for a minor skin burn on the right breast. Overall, the initial operation using the updated platform was safely performed. PMID: 32140275 [PubMed]
Source: Journal of Breast Cancer - Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research
Contributors : Hsin-Tien Tsai ; Ching-Shui Huang ; Chao-Chiang Tu ; Chih-Yi Liu ; Chi-Jung Huang ; Yuan-Soon Ho ; Shih-Hsin Tu ; Ling-Ming Tseng ; Chi-Cheng HuangSeries Type : Expression profiling by arrayOrganism : Homo sapiensMicrocalcification is one of the most common radiological and pathological features of breast ductal carcinoma in situ (DCIS), and to a lesser extent, invasive ductal carcinoma. We evaluated transcriptional profiles associated with ectopic mammary mineralization.We evaluated the transcriptional profiles associated with breast cancer microcalcification for Taiwanese breast cancer and a gene expressio...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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