Twenty-five years of nomenclature and classification of proteolytic enzymes

Publication date: Available online 12 December 2019Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Neil D. RawlingsAbstractProteolytic enzymes and their homologues have been classified into clans by comparing the tertiary structures of the peptidase domains, into families by comparing the protein sequences of the peptidase domains, and into protein-species by comparing various attributes including domain architecture, substrate preference, inhibitor interactions, subcellular location, and phylogeny. The results are compared with the earlier classification by Rawlings & Barrett (Rawlings and Barrett, 1993 [1]). The numbers of sequences, protein-species, families, clans and even catalytic type have substantially increased during the intervening 26 years. The alternative classifications by catalytic type and/or activity are shown not to reflect evolutionary relationships.

Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - December 13, 2019 Category: Biochemistry Source Type: research