Congo-Kinshasa: We Won't Achieve Zero Ebola Cases Until We Get Language Right

[The New Humanitarian] Goma, Democratic Republic of Congo -If a doctor referred to you as a "little criminal", would you trust them?
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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[Concord] Stats SL is all set to collaborate with the John Hopkins University, which is a private research university in Baltimore, Maryland in the United States, to conduct an Ebola survivors study
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: 14 January 2020Source: Cell Reports, Volume 30, Issue 2Author(s): Yoshihiro Takadate, Tatsunari Kondoh, Manabu Igarashi, Junki Maruyama, Rashid Manzoor, Hirohito Ogawa, Masahiro Kajihara, Wakako Furuyama, Masahiro Sato, Hiroko Miyamoto, Reiko Yoshida, Terence E. Hill, Alexander N. Freiberg, Heinz Feldmann, Andrea Marzi, Ayato TakadaSummaryFruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species. Here, we show a molecular basis u...
Source: Cell Reports - Category: Cytology Source Type: research
Fourteen new confirmed cases were reported from 8 to 14 January in the ongoing Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo.
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Viruses, Vol. 12, Pages 106: Modeling Challenges of Ebola Virus–Host Dynamics during Infection and Treatment Viruses doi: 10.3390/v12010106 Authors: Daniel S. Chertow Louis Shekhtman Yoav Lurie Richard T. Davey Theo Heller Harel Dahari Mathematical modeling of Ebola virus (EBOV)–host dynamics during infection and treatment in vivo is in its infancy due to few studies with frequent viral kinetic data, lack of approved antiviral therapies, and limited insight into the timing of EBOV infection of cells and tissues throughout the body. Current in-host mathematical models simplify EBOV infectio...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
n Kuhn Luban Sabeti For highly pathogenic viruses, reporter assays that can be rapidly performed are critically needed to identify potentially functional mutations for further study under maximal containment (e.g., biosafety level 4 [BSL-4]). The Ebola virus nucleoprotein (NP) plays multiple essential roles during the viral life cycle, yet few tools exist to study the protein under BSL-2 or equivalent containment. Therefore, we adapted reporter assays to measure NP oligomerization and virion-like particle (VLP) production in live cells and further measured transcription and replication using established minige...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Chandran Munro The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion membrane with the membrane of susceptible target cells during infection. While proteolytic cleavage of GP by endosomal cathepsins and binding of the cellular receptor Niemann-Pick C1 protein (NPC1) are essential steps for virus entry, the detailed mechanisms by which these events promote membrane fusion remain unknown. Here, we applied single-molecule Förster resonance energy transfer (smFRET) imaging to investigate the structural dynamics of the EBOV GP trimeric ectodomain, and the functional transmembrane p...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Date: Tuesday, 01 14, 2020; Speaker: Daniel Chertow, MD, MPH, CC; Nancy Sullivan, PhD, NIAID; Building: Building 50; 1227/1233; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Condition:   Ebola Interventions:   Biological: Ad26.ZEBOV;   Biological: MVA-BN-Filo;   Biological: Placebo Sponsor:   Janssen Vaccines & Prevention B.V. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
[East African] It was a tumultuous year, research scientists say of 2019, as they point to cholera that swept through Mozambique, threatening the population just as the protracted Ebola crisis hit the Democratic Republic of Congo.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Source: National Institutes of Health (NIH). Published: 1/14/2020. This one-hour, 44-minute presentation discusses how the National Institutes of Health (NIH) has been at the forefront in the global effort to prevent the spread of Ebola virus. NIH staff were deployed in western Africa during the 2015-2016 Ebola outbreak to provide primary care to those infected, and Ebola patients were received at the NIH Clinical Center. For many years prior, NIH scientists studied the natural reservoirs of emerging viruses such as Ebola virus and have elucidated the biology of Ebola virus infection, which has informed the creation of in...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
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