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Phototherapeutic modalities induce apoptosis of keratinocytes and immune cells, impact cytokine production, downregulate the IL-23/Th17 axis, and induce regulatory T cells. As in anti-IL-17 or anti-IL-23 antibody treatment, the dual action of phototherapy on skin and the immune system is likely responsible for sustained resolution of lesions in diseases such as psoriasis. In cutaneous T cell lymphoma, phototherapy may function by causing tumor cell apoptosis and eliminating the neoplastic and inflammatory infiltrate. Further research on phototherapeutic mechanisms will help advance, optimize, and refine dermatologic treatments and may open up novel avenues for treatment strategies in dermatology and beyond.
Source: Dermatologic Clinics - Category: Dermatology Authors: Source Type: research

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AbstractEpigenetics is the study of heritable changes in gene expression that do not originate from alternations in the DNA sequence. Epigenetic modifications include DNA methylation, histone modification, and gene silencing via the action of microRNAs. Epigenetic dysregulation has been implicated in many disease processes. In the field of dermatology, epigenetic regulation has been extensively explored as a pathologic mechanism in cutaneous T-cell lymphoma (CTCL), which has led to the successful development of epigenetic therapies for CTCL. In recent years, the potential role of epigenetic regulation in the pathogeneses o...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
Extramammary Paget Disease (EMPD) is a rare intraepithelial adenocarcinoma that arises in apocrine gland bearing skin and presents as a chronic rash that resembles several disorders such as eczema, cutaneous T cell lymphoma, Langerhans cells histiocytosis, intraepithelial neoplasia, fungal infections and psoriasis. EMPD is often associated with underlying or distant malignancies. The epidemiology of EMPD in Canada is poorly understood. Further, the risk of developing second malignancies in Canadian EMPD patients was not evaluated prior to the presented study.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Cutaneous T-cell lymphoma (CTCL) is a non-Hodgkin lymphoma characterized by infiltrating malignant monoclonal T-lymphocytes. Differential diagnosis of CTCL poses a challenge to clinicians due to its propensity to mimic benign dermatoses such as psoriasis and eczema. Meiosis-specific cancer/testis (meiCT) antigens are a specialized group of genes expressed specifically in meiosis and epigenetically silenced in normal somatic cells, however recent research has demonstrated that a number of meiosis genes are ectopically upregulated in cancers, including CTCL.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research
In this study, we investigated the role of E-FABP in psoriasis vulgaris, atopic dermatitis (AD), and cutaneous T-cell lymphoma (CTCL).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Function Source Type: research
We present a case of a 58-year-old man who presented with 5 years of cutaneous symptoms and several months of fevers and night sweats, ultimately diagnosed as MF. Owing to diffuse CD30 positivity, he was a candidate for brentuximab vedotin, an antibody-drug conjugate medication that selectively targets the CD30 antigen. This resulted in an excellent therapeutic response.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
IL-31 is an IL-6 family cytokine usually associated with allergic inflammation and itch. IL-31 expression is detectable in blood and lesional skin from atopic dermatitis patients, and can be induced by Th2-polarization of mouse or human CD4 T cell clones in vitro. Recently, IL-31 expression has also been reported in non-Th2 itchy inflammatory skin conditions such as cutaneous T cell lymphoma, dermatomyosis, and psoriasis. In psoriasis, IL-31 mRNA expression has not been mapped to any specific cell type.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Neuro-Cutaneous Biology and Inflammation Source Type: research
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Erica S. Tarabadkar† and Michi M. Shinohara*† Division of Dermatology, University of Washington, Seattle, WA, United States Skin directed therapies (SDTs) serve important roles in the treatment of early stage cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF), as well as managing symptoms and improving quality of life of all stages. There are now numerous options for topical therapies that demonstrate high response rates, particularly in early/limited MF. Phototherapy retains an important role in treating MF, with increasing data supporting efficacy and long-term safety of both UVB and PUVA as ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Cioplea M, Caruntu C, Zurac S, Bastian A, Sticlaru L, Cioroianu A, Boda D, Jugulete G, Nichita L, Popp C Abstract Dendritic cells (DCs) are antigen-presenting cells with an important role in the innate and adaptive immune system. In skin lesions, cutaneous DCs (Langerhans cells, dermal DCs and plasmacytoid DCs) are involved in immune activation in inflammatory benign lesions, as well as in malignant lymphoid proliferations. Density and distribution of DCs in the dermal infiltrate can be helpful to differentiate benign, reactive infiltrate from malignant nature of the lymphoid population. We performed a ret...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Ling YL, Huang X, Mitri G, Lovelace B, Pham, Knobler R, Li X, Gao X Abstract INTRODUCTION: The National Comprehensive Cancer Network and the European Organization for Research and Treatment of Cancer recommend extracorporeal photopheresis (ECP) as systemic therapy for cutaneous T-cell lymphoma (CTCL). OBJECTIVE: To investigate real-world use of ECP in CTCL patients in the US. METHODS: Data from the Truven MarketScan® database (2010-2015) were used to create a cohort of CTCL patients receiving systemic treatment. Multivariable regressions were performed to compare health care resource utilizatio...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
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