When Mental Illness Is Severe

Programs ‌ ‌called‌ ‌assertive‌ ‌community‌ ‌treatment‌ ‌provide‌‌‌ ‌the‌ ‌kinds‌ ‌of‌ ‌services‌ ‌offered‌ ‌in‌ ‌psychiatric‌ ‌hospitals‌, ‌within‌ ‌a‌ ‌home‌ ‌setting.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Mental Health and Disorders Murders, Attempted Murders and Homicides Police Brutality, Misconduct and Shootings Prisons and Prisoners Psychiatry and Psychiatrists Schizophrenia Source Type: news

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CONCLUSION: Our findings suggest a relationship between the risk of cardiovascular disease and the duration and overall severity of schizophrenia and also highlights the role of antipsychotics in this relationship. PMID: 31801314 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Publication date: Available online 5 December 2019Source: International Review of NeurobiologyAuthor(s): Teresa Vargas, Rachel E. Conley, Vijay A. MittalAbstractChronic stress exposure has been established as a key vulnerability factor for developing psychotic disorders, including schizophrenia. A structural, or systems level perspective, has often been lacking in conceptualizations of chronic stress for psychotic disorders. The current review thus identified three subtypes of structural exposures. Stimulation exposures included urban environments, population density and crime exposure, with intermediary mechanisms of lack...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 5 December 2019Source: Neuroscience LettersAuthor(s): Md Razib Hossain, Mostofa Jamal, Yu Tanoue, Daiki Ojima, Hiroo Takahashi, Takashi Kubota, Tuba M. Ansary, Asuka Ito, Naoko Tanaka, Hiroshi Kinoshita, Yasushi Kishimoto, Tohru YamamotoAbstractMDGA1 (MAM domain-containing glycosylphosphatidylinositol anchor) has recently been linked to schizophrenia and bipolar disorder. Dysregulation of dopamine (DA) and serotonin (5-HT) systems has long been associated with schizophrenia and other neuropsychiatric disorders. Here, we measured prepulse inhibition (PPI) of the startle response and ex viv...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 5 December 2019Source: NeuronAuthor(s): Sehyoun Yoon, Euan Parnell, Maria Kasherman, Marc P. Forrest, Kristoffer Myczek, Susitha Premarathne, Michelle C. Sanchez Vega, Michael Piper, Thomas H.J. Burne, Lachlan A. Jolly, Stephen A. Wood, Peter PenzesSummaryVariants in the ANK3 gene encoding ankyrin-G are associated with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipolar disorder. However, no upstream regulators of ankyrin-G at synapses are known. Here, we show that ankyrin-G interacts with Usp9X, a neurodevelopmental-disorder-assoc...
Source: Neuron - Category: Neuroscience Source Type: research
Authors: Pershad Y, Guo M, Altman RB Abstract One in five Americans experience mental illness, and roughly 75% of psychiatric prescriptions do not successfully treat the patient's condition. Extensive evidence implicates genetic factors and signaling disruption in the pathophysiology of these diseases. Changes in transcription often underlie this molecular pathway dysregulation; individual patient transcriptional data can improve the efficacy of diagnosis and treatment. Recent large-scale genomic studies have uncovered shared genetic modules across multiple psychiatric disorders - providing an opportunity for an in...
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research
AbstractPurposeMaternal schizophrenia is associated with adverse birth outcomes, but the reasons for this remain unclear. In a population-based cohort of infants born to women with schizophrenia, we determined the occurrence of key perinatal outcomes and explored whether factors identifiable in our datasets explained any elevated risk.MethodsUsing population-level health administrative data linked to clinical birth-registry data in Ontario, Canada (2006 –2011), we examined the relative risk (RR) of preterm birth (
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
Schizophrenia, a multisystem disorder with an unknown etiology, is associated with several immune dysfunctions, including abnormal levels of circulating cytokines. In this review, we investigated the changes of cytokines in schizophrenic patients, their connection with behavioral symptoms severity and their potential clinical implications. We also assessed the possible causative role of abnormal cytokine levels in schizophrenia pathogenesis. Based on meta-analyses, we categorized cytokines according to their changes in schizophrenic patients into four groups: (1) increased cytokines, including interleukin (IL)-6, tumor nec...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, we used gene interaction networks to investigate common gene signatures associated with the above phenotypes. In total, 19 candidate genes were used for making an interaction network which further revealed 39 associated genes (includingKCNA1,SCN2A,CACNA1A,KCNM4,KCNO3,SCN1B andCACNB4) implicated in paroxysmal neurological disorders development and progression. The meta-regression analysis showed the strongest association ofSCN2A with genes involved in schizophrenia and neurodevelopmental disorders. Importantly, our analysis showedKCNMA1 as a common gene signature with a link to epilepsy, movement disorders an...
Source: Neurological Sciences - Category: Neurology Source Type: research
This study used qualitative approach, and data were collected through focus group discussion with seven participants from Melong District Primary Health Centre, West Java. The inclusion criteria were as follows: survivors were diagnosed with schizophrenia, in stable condition, had no impaired cognitive function, have good insight, do not experience mental retention and can communicate well and cooperatively. Data were analysed using the theory of Braun and Clarke to identify key themes.Six themes arose from this study including becoming an agent of recovery, accepting yourself as you are, keeping a smile in all situations,...
Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
Scientists from 22 institutions, including UCLA, are recommending early diagnosis, prevention and treatment of severe chronic inflammation to reduce the risk of chronic disease and death worldwide.The group of international experts, which also includes scientists from the National Institutes of Health, Stanford University, Harvard Medical School, Columbia University Medical Center and University College London, point to inflammation-related diseases as the cause of 50 percent of all deaths worldwide.Inflammation is a naturally occurring response by the body ’s immune system that helps fight illness and infection. Whe...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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