EU financial watchdog criticises lack of progress in tackling antimicrobial resistance

Source: BMJ News - Category: General Medicine Source Type: research

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ConclusionThese data suggest that a combined 2-h infusion with a higher dosage of meropenem, including a loading dose, may be successful to achieve effective PK parameters.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 10 December 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Yuxue Cao, Mahdi Naseri, Yan He, Chun Xu, Laurence J. Walsh, Zyta M. ZioraAbstractBiofilms can be produced by multiple species or by a single strain of bacteria. The biofilm state enhances the resistance of the resident microorganisms to antimicrobial agents by producing extracellular polymeric substances. Typically, antibiotics are used to stop the growth of bacteria, but emerging resistance has limited their effectiveness. Bacteria in biofilms are less susceptible to antibiotics compared with their free-floatin...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
[Daily Maverick] Antimicrobial resistance has been an ongoing threat to public health in South Africa and across Africa. Disturbingly, the burden in Africa from infectious diseases has been on the rise. Part of the reason is the persistence of infections associated with tropical regions as well as the higher rates of poverty and greater spread of drug resistance.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
We investigated antimicrobial resistance trends and characteristics of ESBL-producing Escherichia coli isolates from pets and whether this correlates with antibiotic usage in the clinic. Clinical samples containing E. coli from diseased cats and dogs were screened for antibiotic sensitivity and associated genotypic features. We identified 127 E. coli isolates from 1886 samples from dogs (n = 1565) and cats (n = 321) with the majority from urinary tract infections (n = 108, 85%). High rates of resistance were observed for β-lactams and fluoroquinolones and resistance to> 3 antibiotic classes (MDR) increased from 67%...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionsIn this study, we observed pooled infection estimates of almost 4% in labour and between 1% –2% of each infection outcome postpartum. This indicates maternal peripartum infection is an important complication of childbirth and that preventive efforts should be increased in light of antimicrobial resistance. Incidence risk appears lower than modelled global estimates, although differences in definitions limit comparability. Better-quality research, using standard definitions, is required to improve comparability between study settings and to demonstrate the influence of risk factors and protective interventions.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
AbstractMultidrug-resistant (MDR)Pseudomonas aeruginosa represents a major clinical concern. The interplay between antimicrobial resistance and virulence ofP. aeruginosa was investigated in in vitro and in vivo studies. Thirty-eight well-characterized (21 MDR and 17 non-MDR)P. aeruginosa strains from patients with bacteraemia were analysed. Resistance phenotype, carbapenemase production, clonal relatedness, type III secretion system genotype, O-antigen serotype, cytotoxicity (ability to lyse cells) on A549 cells, and virulence (lethality in nematodes) in aCaenorhabditis elegans model were investigated. MDR strains showed l...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Over the past few decades, antimicrobial resistance has emerged as an important threat to public health due to the global dissemination of multidrug-resistant strains from several bacterial species. This worrisome trend, in addition to the paucity of new antibiotics with novel mechanisms of action in the development pipeline, warrants the development of non-antimicrobial approaches to combating infection caused by these isolates. Monoclonal antibodies (mAbs) have emerged as highly effective molecules for the treatment of multiple diseases. However, in spite of the fact that antibodies play an important role in protective i...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Efthymia Protonotariou, Georgios Meletis, Melania Kachrimanidou, Dimitra Papadopoulou, Aikaterini Stamou, Maria Arhonti, Lemonia Skoura
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Publication date: December 2019Source: Journal of Global Antimicrobial Resistance, Volume 19Author(s):
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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