Low AS160 and high SGK basal phosphorylation associates with impaired incretin profile and type 2 diabetes in adipose tissue of obese patients

Obesity and related metabolic disorders, including type 2 diabetes mellitus (T2DM), alarmingly grow up in the modern society thus representing a serious issue for endocrinology and medicine. Obesity is the major risk factor for T2DM [1], however, not all obese individuals ultimately develop T2DM. Nevertheless, mechanisms linking obesity to T2DM are being extensively studied.

Source: Diabetes Research and Clinical Practice - November 13, 2019 Category: Endocrinology Authors: Iurii S. Stafeev, Igor A. Sklyanik, Kamil A. Yah'yaev, Ekaterina A. Shestakova, Anatoly V. Yurasov, Andrey V. Karmadonov, Alexander V. Chibalin, Mikhail Yu. Menshikov, Alexander V. Vorotnikov, Yelena V. Parfyonova, Marina V. Shestakova Source Type: research