Patient Care Is Wrenching: A Psychiatrist, a Nurse and a Doctor Bare All

Three new books by medical professionals delve into the human emotions involved in tending to the gravely ill.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Books and Literature Seven Signs of Life: Stories from an Intensive Care Doctor (Book) The Soul of Care (Book) Kleinman, Arthur How to Treat People: A Nurse ' s Notes (Book) Case, Molly Abbey, Aiofe Alzheimer s Disease Nursing and Nu Source Type: news

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Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC08267K, CommunicationSongjiao Li, Peipei Wang, Wenqi Feng, Yunhui Xiang, Kun Dou, Zhi-hong Liu Alzheimer ’s disease (AD) is an irreversible neurodegenerative disorder that has a progression closely associated with oxidative stress. It has been speculated that both the intracellular viscosity and H2O2 level in... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 13 December 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Jiaojiao Hu, Huiyong Sun, Haiping Hao, Qiuling ZhengAbstractAmyloid fibrils are found in systemic amyloidosis diseases such as Alzheimer's disease, Parkinson's disease, and type II diabetes. Currently, these diseases are diagnosed by observation of fibrils or plaques, which is an ineffective method for early diagnosis and treatment of disease. The goal of this study was to develop a simple and quick method to predict the possibility and speed of fibril formation before its occurrence. Oligomers generated from seven repre...
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: This study provides information about Aβ plaque burden, tau tangle burden, and neurodegeneration in cognitively unimpaired persons at three levels of genetic risk for AD. Unimpaired APOE ϵ4 HMs can be studied before their 70s to evaluate the understanding of factors, processes, and interventions involved in the predisposition to and prevention of AD, and after their 70s, to discover factors, processes, and interventions involved in the resilience or resistance to and prevention of AD. PMID: 31831374 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 13 December 2019Source: Chemico-Biological InteractionsAuthor(s): Neelima Ayyalasomayajula, Madhuri Bandaru, Prasanna Kumar Dixit, Rajanna Ajumeera, Chellu S. Chetty, Suresh ChallaAbstractEnvironmental pollutant, Lead (Pb) is known to induce neurotoxicity in human. The central nervous system is the most vulnerable to the minute levels of Pb induced toxicity. Pb has been linked to Alzheimer's disease (AD) as a probable risk factor, as it shows epigenetic and developmental link associated with Alzheimer's disease-like pathology. Beta amyloid peptides were considered as the crucial factors i...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Abstract Successive oxidative stress and biochemical changes results in neuronal death and neuritic plaques growth in Alzheimer's disease (AD). Therefore, it is interest to analyze amyloid-βeta precursor protein (APP), beta-secretase 1 (BACE1), presenilin (PSEN1 and PSEN2) genes from brain tissues to gain insights. Development of potential inhibitors for these targets is of significance. EST sequences of 2898 (APP), 539 (BACE1), 786 (PSEN1) and 314 (PSEN2) genes were analyzed in this study. A contig sequences with APP (contigs 1-4), BACE1 (contigs 5-7), PSEN1 (contigs 8, 9, 10, 11), PSEN2 (contigs 13, 14) exc...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
The holidays bring friends and family together for celebrations and the chance to reconnect with people we may not see regularly during the rest of the year. But for people who are the caregivers for a parent, spouse, partner, or other family member who is living with Alzheimer ’s disease or other forms of dementia, the […]Find jobs at  Careers by  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Geriatrics Source Type: blogs
Conclusions: The ameliorative effects of PLP on AD were predicted to be associated with regulating neural cell apoptosis, inflammatory response, and neurotrophy via various pathways such as PI3K-Akt signaling pathway, MAPK signaling pathway, and neurotrophin signaling pathway. PMID: 31827565 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusions:A lighting intervention tailored to maximally entrain the circadian system can improve sleep, mood, and behavior in patients with dementia living in controlled environments.Clinical Trial, title: Methodology Issues in a Tailored Light Treatment for Persons With Dementia, URL:, identifier: NCT01816152.Citation:Figueiro MG, Plitnick B, Roohan C, Sahin L, Kalsher M, Rea MS. Effects of a tailored lighting intervention on sleep quality, rest–activity, mood, and behavior in older adults with Alzheimer disease and related dem...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
ez AI Abstract Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates gene expression through poly(ADP)-ribosylation, resulting in the loosening of chromatin structure. PARP-1 enzymatic activity has been shown to be necessary for the expression of several genes required for memory formation and consolidation. Previously, we showed that nucleolar PARP-1 is significantly decreased in hippocampal pyramidal cells in Alzheimer's disease (AD). We proposed that the displacement of PARP-1 from the nucleolus results in downregulation of new rRNA expression and ribosome biogenesis, leading to cognitive i...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
ConclusionsSince piceatannol and its metabolites possess pleiotropic health ‐promoting activities, it has emerged as a promising nutraceutical candidate for further development. This study also reinforces the importance ofin vivo testing in nutritional researches as the active metabolite(s) may be absent from thein vitro system.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
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