Association of chemokine expression in anterior cruciate ligament deficient knee with patient characteristics: Implications for post-traumatic osteoarthritis

Stromal cell-derived factor-1a (SDF-1 α) and high mobility group box chromosomal protein 1 (HMGB1) are chemokines that can drive post-traumatic osteoarthritis (PTOA) induced by anterior cruciate ligament (ACL) injury. However, the influence of patient characteristics on expression of those chemokines remains unclear. Our aim was to det ermine the relationship between chemokine expression in synovial fluid (SF) of the ACL-deficient (ACL-D) knee and patient characteristics including time from injury, sex, and age.

Source: The Knee - November 10, 2019 Category: Orthopaedics Authors: Lei Ding, Annunziato Amendola, Brian Wolf, Matthew Bollier, John Albright, Quanming Wang, Minchen Wu, Xue Wang, Haiyan Song, Douglas Pedersen, James Martin Source Type: research