Persistence of inflammatory phenotype in residual psoriatic plaques in patients on effective biologic therapy

Many psoriasis patients treated with biologics do not achieve total skin clearance. These patients possess “residual plaques” despite ongoing biologic treatment. To elucidate mechanisms of plaque persistence despite overall good drug response, we studied fifty subjects: psoriasis patients with residual plaques treated with one of three different biologics, untreated patients, and healthy controls. Sk in biopsies from all subjects were characterized using three methods: mRNA expression, histology, and FACS of skin hematopoietic cells.

Source: Journal of Investigative Dermatology - November 8, 2019 Category: Dermatology Authors: Shunya Mashiko, Rebecca M. Edelmayer, Yingtao Bi, Lauren M. Olson, Joseph B. Wetter, Jing Wang, Catherine Maari, Etienne Saint-Cyr Proulx, Vivek Kaimal, Xuan Li, Katherine Salte, Sandra Garcet, Arun K. Kannan, Susan M. Huang, Xiaohong Cao, Zheng Liu, Jame Tags: Original Article Source Type: research