Economic Burden of West Nile Virus Disease Economic Burden of West Nile Virus Disease

Diagnostic and treatment costs associated with West Nile virus can have significant economic impacts for both patients and healthcare systems.Emerging Infectious Diseases
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

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Publication date: 12 November 2019Source: Cell Reports, Volume 29, Issue 7Author(s): Laura R.H. Ahlers, Chasity E. Trammell, Grace F. Carrell, Sophie Mackinnon, Brandi K. Torrevillas, Clement Y. Chow, Shirley Luckhart, Alan G. GoodmanSummaryThe World Health Organization estimates that more than half of the world’s population is at risk for vector-borne diseases, including arboviruses. Because many arboviruses are mosquito borne, investigation of the insect immune response will help identify targets to reduce the spread of arboviruses. Here, we use a genetic screening approach to identify an insulin-like receptor as a...
Source: Cell Reports - Category: Cytology Source Type: research
(Washington State University) A discovery by a Washington State University-led research team has the potential to inhibit the spread of West Nile virus as well as Zika and dengue viruses. The researchers demonstrated that mammalian insulin activated an antiviral immunity pathway in mosquitoes, increasing the insects' ability to suppress the viruses. Since mosquito bites are the most common way humans are infected with West Nile, stopping the virus among the insects would protect human health.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
We describe a case of neuroinvasive WNV presenting with uveomeningitis in a young and otherwise healthy patient.
Source: Journal of NeuroVirology - Category: Neurology Source Type: research
J. Steyn et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
eyel We reviewed the literature on the role of temperature in transmission of zoonotic arboviruses. Vector competence is affected by both direct and indirect effects of temperature, and generally increases with increasing temperature, but results may vary by vector species, population, and viral strain. Temperature additionally has a significant influence on life history traits of vectors at both immature and adult life stages, and for important behaviors such as blood-feeding and mating. Similar to vector competence, temperature effects on life history traits can vary by species and population. Vector, host, and viral...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
G. Valiakos et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
eng Li Cao Ye Flaviviruses, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), Dengue virus (DENV), and West Nile virus (WNV), are important arthropod-borne pathogens that present an immense global health problem. Their unpredictable disease severity, unusual clinical features, and severe neurological manifestations underscore an urgent need for antiviral interventions. Furin, a host proprotein convertase, is a key contender in processing flavivirus prM protein to M protein, turning the inert virus to an infectious particle. For this reason, the current study was planned to evaluate the antiviral ac...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
LaDeau Species interactions that influence the performance of the exotic mosquito Culex pipiens can have important effects on the transmission risk of West Nile virus (WNV). Invasive plants that alter the vegetation communities of ephemeral ground pools may facilitate or resist the spread of C. pipiens (L.) by altering allochthonous inputs of detritus in those pools. To test this hypothesis, we combined field surveys of roadside stormwater ditches with a laboratory microcosm experiment to examine relationships between C. pipiens performance and water quality in systems containing detritus from invasive Phragmites aust...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Abstract Flaviviruses comprise several medically important viruses, including Japanese encephalitis virus, West Nile virus, dengue virus (DENV), yellow fever virus and Zika virus (ZIKV). A large outbreak of DENV and ZIKV occurred recently, leading to many cases of illness and death. However, despite decades of efforts, we have no clinically specific therapeutic drugs against DENV and ZIKV. Previous studies showed that inflammatory responses play a critical role in dengue and Zika pathogenesis. Thus, in this study, we examined a series of novel anti-inflammatory compounds and found that treatment with compound 2d c...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
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