It's About Time: Transfusion effects on postinjury platelet aggregation over time

CONCLUSION Controversy exists on whether transfusions improve impaired postinjury platelet aggregation. Using regression modeling, we identified that expected transfusion effects on subsequent platelet aggregation are maximal with platelet transfusion given late after injury. This is critical for tailored resuscitation, identifying a potential early period of resistance to platelet transfusion that resolves by 96 hours. LEVEL OF EVIDENCE Therapeutic, level V.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: 2019 WTA PODIUM PAPERS Source Type: research