Slight setback in lung transplant girl's recovery: Mom
Doctors treating Sarah Murnaghan, 10, had to reinsert breathing tube they tried to remove; not seen as dimming long-term outlook, mom says
Tiffany Senter (pictured) of Shasta Lake City, California is only 25, but she's been at deaths door twice. Tiffany was born with cystic fibrosis and has had to have two lung transplants.
Sepsis is a dynamic disease, displaying an inflammatory profile that varies over time and for each organ. Controlling the inflammatory response based in targeting a single molecule has been proved useless. We hypothesized that treatment with bone marrow-derived mononuclear cells (BMDMCs) may be more efficient to modulate the systemic inflammatory response to infection. Adult male Balb/c mice were subjected to cecal ligation and puncture (CLP) or endotoxemia model of experimental sepsis. BMDMCs were separated under Ficoll gradient and injected intravenously 1 h after the procedures. Cytokines concentration was quantified in...
The objective of our study was to evaluate the impact of CAS on lung function after lung transplantation. MATERIAL AND METHODS All lung transplant recipients from June 2009 to August 2014 in a single center (Strasbourg, France) were retrospectively reviewed. RESULTS A total of 191 lung transplantations were performed: 175 bilateral, 15 single, and 1 heart-lung transplantation. Of the 161 bilateral lung-transplanted patients who survived>3 months, 22 (13.6%) developed CAS requiring endobronchial treatment. All these patients were treated by endoscopic balloon dilatation, and 9 additionally needed endobronchial stents. Re...
Publication date: Available online 11 February 2019Source: The Annals of Thoracic SurgeryAuthor(s): Charles D. Fraser, Xun Zhou, Joshua C. Grimm, Alejandro Suarez-Pierre, Todd C. Crawford, Cecillia Lui, Errol L. Bush, Narutoshi Hibino, Marshall L. Jacobs, Luca A. Vricella, Christian MerloAbstractBackgroundThe impact of size mismatch between donor and recipient in pediatric lung transplantation (PLTx) is currently unknown. Previous studies in adults have suggested that oversized allografts are associated with improved outcomes following lung transplantation. We investigated this relationship in order to quantify its effect ...
A 50-yearold lady presented to hospital with blurred vision and pyrexia. She had previously undergone a renal transplant and was on standard immunosuppression therapy. In addition, she had recently been treated for invasive pulmonary aspergillosis. On this admission, she was diagnosed with endophthalmitis and a right ankle abscess. She was started on broad spectrum antimicrobials and the ankle collection was drained. She continued to have febrile episodes and a transthoracic echocardiogram revealed an echogenic mass in the left ventricle (Image 1 ░A).
This study aimed to establish the safety of anti-fibrotic therapy in the peri-transplant period, particularly with regards to healing of the bronchial anastomosis.
Outflow graft obstruction is a known and described complication following continuous-flow (CF) left ventricular assist device (LVAD) implantation1. Mechanisms include anastomotic stenosis, angulation, twisting, and external impingement from protective outer sleeves2. Although non-interventional strategies may be employed, physiologically important outflow graft obstruction typically requires intervention.