Cell of Origin and Immunological Events in the Pathogenesis of Breast Implant –Associated Anaplastic Large Cell Lymphoma

Breast implant –associated anaplastic large cell lymphoma (BIA-ALCL) is a CD30-positive, anaplastic lymphoma kinase–negative T-cell lymphoma. Nearly all cases have been associated with textured implants. Most cases are of effusion-limited, indolent disease, with an excellent prognosis following implant and cap sule removal. However, capsular invasion and tumor mass has a more aggressive course, and a fatal outcome risk. This review summarizes the current knowledge on BIA-ALCL cell of origin and immunological factors underlying its pathogenesis.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research