IL-17C is Elevated in Lesional Tissue of Hidradenitis Suppurativa.

IL-17C is Elevated in Lesional Tissue of Hidradenitis Suppurativa. Br J Dermatol. 2019 Sep 26;: Authors: Navrazhina K, Frew JW, Krueger JG Abstract Interleukin 17C (IL-17C) is a cytokine produced by epithelial cells, including keratinocytes, in response to multiple stimuli1 such as IL-17A, IL-17F, TNF-α, bacterial stimuli and toll-like receptor agonists1 . When produced in keratinocytes, IL-17C mediates the production of inflammatory molecules, including IL-1β, IL-8, CXCL1, and IL-36γ. In addition, IL-17C induces further elevation in IL-17A and IL-17F in Th17 cells in a pro-inflammatory positive amplification loop2,3 . PMID: 31556100 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research